role of 5-hydroxytryptamine 1a receptors in 6-hydroxydopmaine-induced catalepsy-like immobilization in rats: a therapeutic approach for treating catalepsy of parkinson’s disease

Authors

siamak reyhani-rad science and research branch, islamic azad university, tehran, iran.

alireza nayebi department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences. drug applied research center, tabriz university of medical sciences.

javad mahmoudi neurosciences research center (nsrc), tabriz university of medical sciences, tabriz iran.

morteza samini science and research branch, islamic azad university, tehran, iran.

abstract

we have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1a (5-ht1a) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-ohda) and haloperidol in rats. the present work extends these findings by investigating the role of 5-ht1a receptors on catalepsy-like immobilization in rats, a model of parkinson’s disease. catalepsy was induced by unilateral infusion of 6-oh-dopamine (8 µg/2µl/rat) into the central region of the substantia nigra, compact part (snc) and assayed by bar-test method 5, 60, 120 and 180 min after the drugs administration. the involvement of 5-ht1a receptors in 6-ohda-induced catalepsy was studied through intraperitoneal (0.25, 0.5 and 1mg/kg ip) and intrasubstantia nigra, compact part (10 µg/rat, intra-snc) injection of 8-hydroxy-2-[di-n-propylamino] tetralin (8-ohdpat) as well as administration of 1-(2-methoxyphenyl)-4-[4-(2-pthalimmido) butyl] piperazine hydrobromide (0.1, 0.5 and 1 mg/kg, nan-190, ip). nan-190 (1 mg/kg, ip) and 8-ohdpat (1 mg/kg, ip and 10 µg/rat, intra-snc) increased and decreased 6-ohda-induced catalepsy respectively. in normal (non 6-ohda-lesioned) rats, nan-190 (1 mg/kg, ip) increased the elapsed time in bar-test while 8-ohdpat did not produce any significant effect. the anticataleptic effect of 8-ohdpat (1 mg/kg, ip) was reversed markedly by co-injection with nan-190 (1 mg/kg, ip). these findings suggest that 5-ht1a receptors are involved in 6-ohda-induced catalepsy-like immobilization.

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Journal title:

the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۴، صفحات ۱۱۷۵-۱۱۸۱

Keywords

[ 5 , ' h t 1 a ' , 6 , ' h y d r o x y d o p a m i n e ' , 8 , ' o h d p a t ' , ' n a n ' , 1 9 0 , ' c a t a l e p s y ' ]

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